Theodore R Cummins Selected Research

Paroxysmal Extreme Pain Disorder

10/2011	Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.
9/2011	Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.
2/2011	Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.
1/2010	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.
9/2008	Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable.
9/2008	Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation.

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Theodore R Cummins Research Topics

Disease

22	Pain (Aches) 01/2022 - 04/2004
6	Epilepsy (Aura) 01/2022 - 01/2010
6	Neuralgia (Stump Neuralgia) 01/2019 - 05/2006
6	Paroxysmal Extreme Pain Disorder 10/2011 - 09/2008
5	Erythromelalgia (Erythermalgia) 10/2011 - 09/2004
5	Chronic Pain 09/2011 - 10/2007
4	Inflammation (Inflammations) 04/2016 - 04/2004
3	Cardiac Arrhythmias (Arrythmia) 01/2018 - 01/2010
2	Glaucoma 01/2020 - 01/2016
2	Heart Failure 01/2018 - 06/2012
2	Hypersensitivity (Allergy) 04/2016 - 09/2011
2	Painful Neuropathy 09/2008 - 09/2004
1	Drug Resistant Epilepsy 04/2020
1	Huntington Disease (Huntington's Disease) 02/2020
1	Seizures (Absence Seizure) 09/2019
1	Small Fiber Neuropathy 01/2019
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2019
1	Optic Nerve Diseases (Optic Neuropathy) 01/2016
1	Epileptic Syndromes 01/2016
1	Headache (Headaches) 04/2014
1	Toothache (Toothaches) 04/2014
1	Eye Pain 04/2014
1	Long QT Syndrome 10/2012
1	Brugada Syndrome 06/2012
1	Ischemia 03/2012
1	Traumatic Brain Injuries (Traumatic Brain Injury) 03/2012
1	Demyelinating Diseases (Demyelinating Disease) 09/2011
1	Migraine Disorders (Migraine) 09/2011
1	Bites and Stings (Sting) 01/2011
1	Sudden Infant Death (SID) 01/2010
1	Myotonic Disorders (Paramyotonia Congenita) 01/2010
1	Channelopathies 01/2010
1	Myotonia 01/2010
1	Flushing 09/2008
1	Cardiotoxicity 05/2006
1	Diabetic Nephropathies (Diabetic Nephropathy) 08/2002
1	Diabetes Mellitus 08/2002

Drug/Important Bio-Agent (IBA)

19	Voltage-Gated Sodium ChannelsIBA 01/2022 - 04/2004
19	Sodium Channels (Sodium Channel)IBA 01/2019 - 04/2004
11	Protein Isoforms (Isoforms)IBA 01/2017 - 05/2006
8	SodiumIBA 01/2022 - 07/2008
5	Pharmaceutical PreparationsIBA 01/2021 - 01/2011
5	Tetrodotoxin (Tetradotoxin)IBA 04/2016 - 04/2004
5	Sodium Channel BlockersIBA 10/2011 - 05/2006
4	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2022 - 03/2012
4	Peptides (Polypeptides)IBA 01/2017 - 02/2011
4	Lidocaine (Xylocaine)FDA LinkGeneric 10/2012 - 06/2007
3	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2022 - 06/2012
3	VenomsIBA 01/2021 - 01/2011
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2019
2	Anticonvulsants (Antiepileptic Drugs)IBA 04/2020 - 01/2016
2	Scorpion Venoms (Scorpion Venom)IBA 10/2013 - 01/2011
2	Amino Acids FDA Link 10/2013 - 09/2011
2	Carbamazepine (Tegretol)FDA LinkGeneric 10/2011 - 07/2008
2	Voltage-Gated Sodium Channel BlockersIBA 01/2011 - 11/2007
1	Superoxides (Superoxide)IBA 02/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2019
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2018
1	CalciumIBA 01/2018
1	PotassiumIBA 01/2018
1	Small Interfering RNA (siRNA)IBA 04/2016
1	CannabinoidsIBA 01/2016
1	SolutionsIBA 01/2016
1	Leucine (L-Leucine)FDA Link 01/2016
1	Arginine (L-Arginine)FDA Link 01/2016
1	Histidine (L-Histidine)FDA Link 01/2016
1	AsparagineIBA 01/2016
1	Lysine (L-Lysine)FDA Link 01/2016
1	Valine (L-Valine)FDA Link 01/2016
1	Aspartic Acid (Aspartate)FDA Link 01/2016
1	CannabidiolIBA 01/2016
1	Furocoumarins (Furanocoumarins)IBA 04/2014
1	imperatorinIBA 04/2014
1	Glutamic Acid (Glutamate)FDA Link 03/2012
1	Calcium Channels (Calcium Channel)IBA 09/2011
1	Lacosamide FDA Link 07/2008
1	Analgesics (Analgesic Drugs)IBA 05/2006
1	Local AnestheticsIBA 05/2006
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 05/2006
1	CarrageenanIBA 04/2004
1	Messenger RNA (mRNA)IBA 04/2004
1	Vasopressins (Vasopressin)IBA 08/2002

Therapy/Procedure

5	Therapeutics 01/2011 - 08/2007
3	Drug Therapy (Chemotherapy) 04/2020 - 01/2010
1	Microelectrodes 04/2016
1	Traditional Medicine (Folk Remedies) 04/2014
1	Analgesia 10/2013